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Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway Free
Chunming Liu 1 and Xi He2,*
1Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA
2F.M. Kirby Neurobiology Center, Children's Hospital Boston, Harvard Medical School, CLS 12064, 3 Blackfan Street, Boston, MA 02115, USA *Correspondence to:Xi He, E-mail: xi.he@childrens.harvard.edu
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 70-73,  https://doi.org/10.1093/jmcb/mjp040

A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/β-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a β-catenin destructor.

Volume 2, Issue 2
April 2010